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The antiemetic properties of metoclopramide appear to be a result of its antagonism of central and peripheral dopamine receptorsDopamine produces nausea and vomiting by stimulation of the medullary chemoreceptor trigger zoneCTZand metoclopramide blocks stimulation of the CTZ by agents like ldopa or apomorphine which are known to increase dopamine levels or to possess dopamine-like effectsMetoclopramide also abolishes the slowing of gastric emptying caused by apomorphine.

There have been rare reports of an uncommon but potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant SyndromeNMSassociated with metoclopramideClinical manifestations of NMS include hyperthermiamuscle rigidityaltered consciousnessand evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresis and cardiac arrhythmias

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Reglan Injection may be used to stimulate gastric emptying and intestinal transit of barium in cases where delayed emptying interferes with radiological examination of the stomach and/or small intestine.

Galactorrheaamenorrheagynecomastiaimpotence secondary to hyperprolactinemiasee PRECAUTIONSFluid retention secondary to transient elevation of aldosteronesee CLINICAL PHARMACOLOGY

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chronic use of reglan metoclopramide has been linked to tardive dyskinesia, which may include involuntary and repetitive movements of the body, even after the drugs are no longer taken.